Uniquely conserved immunosuppressive viral exoribonucleases
نویسندگان
چکیده
منابع مشابه
Uniquely conserved immunosuppressive viral exoribonucleases
The interplay between viruses and host immune responses is critical to determine either a successful infection or resolution. Mammalian cells have developed different mechanisms to recognize invading pathogens via their pathogen-associated molecular patterns (PAMPs), which are often nucleic acid products (e.g., doublestranded RNAs or dsRNA) generated during viral genome replication [1]. To evad...
متن کاملThe Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases
We identified a complex in S. cerevisiae, the "exosome," consisting of the five essential proteins Rrp4p, Rrp41p, Rrp42p, Rrp43p, and Rrp44p (Dis3p). Remarkably, four of these proteins are homologous to characterized bacterial 3'-->5' exoribonucleases; Rrp44p is homologous to RNase II, while Rrp41p, Rrp42p, and Rrp43p are related to RNase PH. Recombinant Rrp4p, Rrp44p, and Rrp41p are 3'-->5' ex...
متن کاملPromiscuous exoribonucleases of Escherichia coli.
RNases play a central role in the metabolism of RNA. Among the many reactions catalyzed by these enzymes are those that separate individual entities of multicomponent transcripts, those that generate the mature 5' and 3' termini of RNAs, and those that remove introns. RNases also degrade RNA molecules that are no longer needed by the cell or that are damaged in some way, and under some conditio...
متن کاملSirtuins Are Evolutionarily Conserved Viral Restriction Factors
UNLABELLED The seven human sirtuins are a family of ubiquitously expressed and evolutionarily conserved NAD(+)-dependent deacylases/mono-ADP ribosyltransferases that regulate numerous cellular and organismal functions, including metabolism, cell cycle, and longevity. Here, we report the discovery that all seven sirtuins have broad-range antiviral properties. We demonstrate that small interferin...
متن کاملEvolutionarily conserved function of a viral microRNA.
MicroRNAs (miRNAs) are potent RNA regulators of gene expression. Some viruses encode miRNAs, most of unknown function. The majority of viral miRNAs are not conserved, and whether any have conserved functions remains unclear. Here, we report that two human polyomaviruses associated with serious disease in immunocompromised individuals, JC virus and BK virus, encode miRNAs with the same function ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14548